Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications
نویسندگان
چکیده
منابع مشابه
Depot-specific differences in angiogenic capacity of adipose tissue in differential susceptibility to diet-induced obesity
OBJECTIVE Adipose tissue (AT) expansion requires AT remodeling, which depends on AT angiogenesis. Modulation of AT angiogenesis could have therapeutic promise for the treatment of obesity. However, it is unclear how the capacity of angiogenesis in each adipose depot is affected by over-nutrition. Therefore, we investigated the angiogenic capacity (AC) of subcutaneous and visceral fats in lean a...
متن کاملSignals from adipose tissue in morbid obesity and effect on depot specific differences
DECLARATION No part of this thesis has been submitted in support of an application for any degree or qualification of the University College London or any other University or Institute of learning. All the work presented is my own and any collaboration has been acknowledged. 3 ABSTRACT Signals from adipose tissue, such as interleukin-6 (IL-6) and asymmetric dimethyl arginine (ADMA), an endogeno...
متن کاملVascular Medicine Depot-Specific Differences and Insufficient Subcutaneous Adipose Tissue Angiogenesis in Human Obesity
Background—Adipose tissue expands in response to excess caloric intake, but individuals prone to deposit visceral instead of subcutaneous adipose tissue have higher risk of metabolic disease. The role of angiogenesis in the expandability of human adipose tissue depots is unknown. The objective of this study was to measure angiogenesis in visceral and subcutaneous adipose tissue and to establish...
متن کاملDepot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity.
BACKGROUND Adipose tissue expands in response to excess caloric intake, but individuals prone to deposit visceral instead of subcutaneous adipose tissue have higher risk of metabolic disease. The role of angiogenesis in the expandability of human adipose tissue depots is unknown. The objective of this study was to measure angiogenesis in visceral and subcutaneous adipose tissue and to establish...
متن کاملIntrinsic Depot-Specific Differences in the Secretome of Adipose Tissue, Preadipocytes, and Adipose Tissue–Derived Microvascular Endothelial Cells
OBJECTIVE Visceral adipose tissue (VAT) is more closely linked to insulin resistance than subcutaneous adipose tissue (SAT). We conducted a quantitative analysis of the secretomes of VAT and SAT to identify differences in adipokine secretion that account for the adverse metabolic consequences of VAT. RESEARCH DESIGN AND METHODS We used lectin affinity chromatography followed by comparison of ...
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ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2013
ISSN: 0098-2997
DOI: 10.1016/j.mam.2012.10.001